200 stereotactic biopsies were evaluated. The validity of the intraope
rative histopathological results were compared with the final diagnosi
s using conventional embedding and staining techniques. Further compar
ison between the histology of the biopsy and the post mortem or open o
perative findings were possible in 41 cases. Discrepancy was found in
one case regarding the tumor detection, and in three cases regarding t
he tumor grading. The mortality in our patients was 1% and the morbidi
ty 3%. Stereotactical biopsy had a low risk even in deep brain regions
such as basal ganglia, mesencephalon, and pons. At the same time the
high histologic validity makes the CT-guided stereotactical biopsy rec
omendable in all lesions not operated by an open resection before any
conservative or palliative therapy is started.