HLA-TYPE OF CEREBRAL VASOSPASM PATIENTS AFTER ANEURYSMAL SUBARACHNOIDHEMORRHAGE

We studied human lymphocyte antigen (HLA) types in a group of 45 patie nts who had aneurysmal subarachnoid hemorrhage (SAH). A significantly increased frequency of HLA antigen A31 and a significantly decreased f requency of HLA antigen B40 were found. In patients with delayed ische mic neurological deficit (DIND) following aneurysmal SAH and HLA typin g, HLA-Bw60 antigen showed significant increases; in patients who did not develop HLA-Aw33 and -Cw4 antigens showed significant. Among the p atients with Fisher's Group 3 on CT, in particular, these antigens sig nificantly increased when compared with controls from the same geograp hic area. These results suggest that HLA-Bw60 antigen plays a role as a predisposing factor of DIND resulting from vasospasm following aneur ysmal SAH, and that HLA-Aw33 and -Cw4 exert protective influence again st DIND.