BRAIN METASTASIS FROM ENDOMETRIAL CARCINOMA - REPORT OF 2 CASES

The authors report two cases of surgically treated brain metastases fr om endometrial cancer which are quite unusual occurrences. In one of t hem the brain lesion was the presenting symptom of malignancy while in the other the metastasis was discovered after the primary tumor had b een treated. Both the brain lesions were scarcely differentiated adeno carcinomas which closely resembled the uterine primaries histologicall y. The authors review the four cases reported in the literature and di scuss the clinical features and the treatment of this disease. The ana lysis of cases shows that the metastatic potential of endometrial canc er is extremely variable and unpredictable but less severe than that o bserved in ovarian or cervical tumors. The authors suggest that the er ratic behaviour of endometrial cancer may justify an aggressive (thoug h necessarily palliative) approach to brain metastases even in the pre sence of circumscribed metastatic involvement.