EFFECTS OF M-NIFEDIPINE AND NIFEDIPINE ON HEMODYNAMICS IN RENOVASCULAR HYPERTENSIVE RATS

In the renovascular hypertensive myocardial hypertrophic rats of preve ntion and regressive groups, the blood pressure was lowered by m-nifed ipine ( m-Nif ) or nifedipine (Nif) of 20 mg.kg-1.d-1, ig, for 9 wk vs control (LVH ) group (P < 0.01). From the isolated working hearts of prevention and regressive groups , it was found that AP, LVSP, +dp/dt( max) -dp/dt(max), CF, and CI values of m-Nif and Nif groups increased higher than that of LVH group, but LVEDP and T was lower in m-Nif and Nif groups, It was concluded that m-Nif exhibits the similar effects l ike Nif in prevention and reversion of renovascular hypertensive LVH a nd improvement of hemodynamics.