The purpose of this study was to determine the nature and extent of co
morbidity among patients with DSM-III-R hypochondriasis and to examine
the relationships between this disorder and coexisting psychiatric il
lness. For this purpose, patients seen in a general medicine clinic we
re screened using measures of hypochondriacal attitudes and somatic sy
mptoms. Those scoring above an established cutoff were given a structu
red diagnostic interview. In this manner, 50 patients who met DSM-III-
R criteria for hypochondriasis and 50 age- and sex-matched controls we
re identified. The presence of other psychiatric disorders (current an
d past) was determined by means of the same diagnostic interview. More
hypochondriacal subjects (62.0%) had lifetime comorbidity than did co
ntrols (30.0%). Major depression, the most frequent comorbid disturban
ce, was usually current and most Often had an onset after that of hypo
chondriasis. Panic disorder with agoraphobia, the most frequent anxiet
y disorder, was also current but Often began before or at the same tim
e as hypochondriasis. Few subjects met criteria for somatization disor
der but a third qualified for a subsyndromal form of this disorder. Th
e data show that, in medical outpatients with hypochondriasis, mood an
d anxiety disorders frequently coexist. This comorbidity is subject to
varying interpretations including overlap of symptom criteria, treatm
ent-seeking bias, and the possibility that hypochondriasis predisposes
to or causes the comorbid disorder, as seems likely in the case of de
pression. In some instances hypochondriasis may be an associated featu
re of another illness.