OSSIFIED SOMATOTROPINOMA

Calcification of pituitary adenomas as a histopathologic finding is re ported in up to 25% of all degenerated adenomas. On the other hand, os sification of these adenomas is an extremely rare finding, with only o ne reported case, a prolactinoma. Here, we report a case of somatotrop inoma in a 42-year-old acromegalic female. The adenoma, about 2 cm in diameter, was removed by the transsphenoidal route. Pathologic examina tion revealed ossification areas in the adenoma and the patient showed dramatic progress with relief of acromegaly signs and normalization o f serum growth hormone levels. This case seems to be a unique report o f osteoid metaplasia of a somatotropinoma.