CLINICAL, ANAMNESTIC AND COAGULATION DATA IN PATIENTS WITH SUSPECTED OR CONFIRMED PULMONARY-EMBOLISM

We studied 84 consecutive patients referred with the suspicion of pulm onary embolism (PE) to investigate the influence of clinical and hemat ological profiles on the diagnosis and severity of this disease and re covery. Diagnosis of PE was confirmed in 48 out of 84 patients by perf usion scintigraphy and/or pulmonary arteriography. Severity of PE and entity of recovery were investigated by measuring standard PaO2 on blo od gas analysis and the number of unperfused lung segments ULS on perf usion scintigraphy. Most common clinical predisposing conditions were more frequent, though not significantly so, in embolic patients and a very low prevalence of PE was appreciable in patients without clear pr edisposing conditions. Among coagulation factors, only thrombin-antith rombin (TAT) complexes were twice as high in embolic as in nonembolic patients (14.0 +/- 13.6 vs. 7.0 +/- 4.2 ng/ml; p < 0.02), while there was no statistically significant difference between embolic and nonemb olic patients for activated partial thromboplastin time, prothrombin t ime, antithrombin III, protein C, fibrinogen, plasminogen, alpha(2)-pl asmin inhibitor, and plasminogen activator inhibitor-1. Sensitivity an d specificity of TAT complexes in diagnosis of PE were 95.8% and 30.5% , respectively. Therefore, normal values of TAT complexes may help exc lude the diagnosis of PE, while abnormal values allow to reinforce the clinical suspicion of PE. No relation was found between coagulation p arameters and the severity of PE. The follow-up of 48 patients with co nfirmed PE was favorable on the average; however, neither the presence of predisposing conditions nor abnormal coagulation parameters allow to predict the degree of functional and scintigraphic improvement duri ng follow-up.