OXIDATION OF STEROIDAL 5-EN-3-BETA-OLS WITH JONES REAGENT IN ETHER

Authors
SOLAJA BA MILIC DR DOSENMICOVIC LI
Citation
Ba. Solaja et al., OXIDATION OF STEROIDAL 5-EN-3-BETA-OLS WITH JONES REAGENT IN ETHER, Steroids, 59(5), 1994, pp. 330-334
Citations number
19
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
59
Issue
5
Year of publication
1994
Pages
330 - 334
Database
ISI
SICI code
0039-128X(1994)59:5<330:OOS5WJ>2.0.ZU;2-P
Abstract
The two-phase oxidation of steroidal 5-en-3 beta-ol (via 5-en-3-ones) into corresponding 4-en-3,6-diones in diethyl ether with Jones reagent ,vas investigated. It was found that the system Jones reagent/diethyl ether enables during oxidation, together with molecular mechanics (MM2 ), and semiempirical (PM3) calculations, suggest that boat conformatio n of ring A precedes the formation of corresponding radicals (or catio ns).