CONFORMATIONAL STUDY OF 3 ENDOTHELIN ANTAGONISTS WITH H-1-NMR AT LOW-TEMPERATURE AND MOLECULAR-DYNAMICS

Authors
VERHEYDEN P VANASSCHE I BRICHARD MH DEMAUDE T PAYE I SCARSO A VANBINST G
Citation
P. Verheyden et al., CONFORMATIONAL STUDY OF 3 ENDOTHELIN ANTAGONISTS WITH H-1-NMR AT LOW-TEMPERATURE AND MOLECULAR-DYNAMICS, FEBS letters, 344(1), 1994, pp. 55-60
Citations number
14
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
344
Issue
1
Year of publication
1994
Pages
55 - 60
Database
ISI
SICI code
0014-5793(1994)344:1<55:CSO3EA>2.0.ZU;2-M
Abstract
The conformations of three endothelin antagonists, a cyclic pentapepti de, a linear tripeptide and a linear hexapeptide, are compared by H-1 NMR and molecular dynamics. The three analogues have a Leu and a DTrp side chain which are oriented parallel, and an acidic group next to th e DTrp residue.