P. Verheyden et al., CONFORMATIONAL STUDY OF 3 ENDOTHELIN ANTAGONISTS WITH H-1-NMR AT LOW-TEMPERATURE AND MOLECULAR-DYNAMICS, FEBS letters, 344(1), 1994, pp. 55-60
The conformations of three endothelin antagonists, a cyclic pentapepti
de, a linear tripeptide and a linear hexapeptide, are compared by H-1
NMR and molecular dynamics. The three analogues have a Leu and a DTrp
side chain which are oriented parallel, and an acidic group next to th
e DTrp residue.