CHARACTERIZATION OF PERIPHERAL-BLOOD LYMP HOCYTE SUBSETS IN PATIENTS WITH BAKERS ASTHMA

Authors
WITTEMANN B SOHMEN R ROSENAU C RADANT S GRIESHABER R
Citation
B. Wittemann et al., CHARACTERIZATION OF PERIPHERAL-BLOOD LYMP HOCYTE SUBSETS IN PATIENTS WITH BAKERS ASTHMA, Allergologie, 17(4), 1994, pp. 166-168
Citations number
NO
Categorie Soggetti
Allergy
Journal title
Allergologie → ACNP
ISSN journal
03445062
Volume
17
Issue
4
Year of publication
1994
Pages
166 - 168
Database
ISI
SICI code
0344-5062(1994)17:4<166:COPLHS>2.0.ZU;2-E
Abstract
Differences in peripheral-blood lymphocyte subsets and activation mark ers were detected in patients with bakers' asthma compared to normal c ontrols. Most asthmatic bakers were characterized by increased numbers of CD4+/HLA-DR+ T cells, by CD8+/HLA-DR+ T cells, by CD4-/CD25+ cells as well as CD19+/CD23+ B cells. Furthermore asthmatic bakers showed e levated serum levels of soluble IL-2 receptor (sCD25) and soluble low- affinity Fc IgE receptor. These differences in the distribution and ac tivation state of peripheral-blood lymphocyte suggest an important rol e of T cells in the pathogenesis of bakers' asthma.