WHOLE-BODY OXYGEN-UPTAKE IS NOT A GOOD INDICATOR OF LIVER ALLOGRAFT FUNCTION FOLLOWING ORTHOTOPIC LIVER-TRANSPLANTATION

Variations of whole body oxygen uptake (VO2) have been studied during orthotopic liver transplantation. Some authors have suggested that the increase in VO2 after revascularization of the graft could be an inde x of good function of the grafted liver and thus low VO2 an early sign of primary non-function. The purpose of our study was to assess the t emporal course of measured respiratory VO2 and to compare the VO2 chan ges to indicators of hepatic function. We used a metabolic monitor (De ltatrac, Datex Corp. Finland) to measure VO2 in 18 patients during tra nsplantation. Clotting factors II and V at 1, 3, 7, 14 and 21 days pos t-operatively and peak serum transaminases within the first 3 post-ope rative days were determined. Variations of VO2 were a decrease during the anhepatic phase and an increase following the reperfusion phase as compared to the VO2 value obtained at the beginning of the procedure. No correlation was found between the increase in VO2 after reperfusio n of the graft and either factor II (r=0.33-0.4), factor V (r=0.23-0.4 3) or peak transaminases (r=0.13). One patient developed a primary non -function of the graft. For this patient VO2) increased far above the pre-anhepatic values. The authors conclude that VO2 is not a reliable sign of graft function.