A. Mori et al., REGULATION OF INTERLEUKIN-5 PRODUCTION BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM ATOPIC PATIENTS WITH FK506, CYCLOSPORINE-A AND GLUCOCORTICOID, International archives of allergy and immunology, 104, 1994, pp. 32-35
Upon stimulation with phorbol ester and ionomycin, peripheral blood mo
nonuclear cells (PBMC) of atopic patients with moderate eosinophilia p
roduced significantly higher amounts of IL-5 compared to that of norma
l subjects. This finding renders further support to the notion that T
cell-eosinophilic inflammation plays a central role in allergic disord
ers. IL-5 induction in vitro was completely inhibited by immunosuppres
sant FK506, cyclosporin A and dexamethasone. FK506 applied in vivo eff
ectively suppressed clinical symptoms of atopic dermatitis and IL-5 pr
oduction of PBMC. FK506 and cyclosporin A may become a better therapeu
tic modality against allergic diseases.