IRRADIATION OF THE SKIN AND SYSTEMIC GRAFT-VERSUS-HOST DISEASE SYNERGIZE TO PRODUCE CUTANEOUS LESIONS

Citation
J. Desbarats et al., IRRADIATION OF THE SKIN AND SYSTEMIC GRAFT-VERSUS-HOST DISEASE SYNERGIZE TO PRODUCE CUTANEOUS LESIONS, The American journal of pathology, 144(5), 1994, pp. 883-888
Citations number
35
Categorie Soggetti
Pathology
ISSN journal
00029440
Volume
144
Issue
5
Year of publication
1994
Pages
883 - 888
Database
ISI
SICI code
0002-9440(1994)144:5<883:IOTSAS>2.0.ZU;2-D
Abstract
In this report, the relationship between irradiation and graft-versus- host disease (GVHD)-induced cutaneous injury was investigated Unirradi ated F1 hybrid mice were grafted with irradiated skin and then injecte d with parental strain lymphoid cells to induce GVHD. Although low gra de dermal lymphoid infiltrates were observed is unirradiated skin graf ts of some GVH-reactive mice, and irradiated grafts of normal animals showed occasional fibrosis, only the irradiated grafts of GVH-reactive mice developed lesions consisting of vacuolar degeneration of the epi dermal-dermaljunction and necrotic keratinocytes accompanied by pronou nced epidermal infiltrates, characteristic of clinical cutaneous GVHD. The results suggest that cutaneous irradiation exerts a permissive ef fect on lesion formation in the skin of mice undergoing GVHD. Furtherm ore, systemic irradiation, known to exacerbate the severity of GVHD, i s not required. Cutaneous lesions may be triggered by radiation injury of keratinocytes, up-regulation of adhesion molecules on irradiated e ndothelium, destruction of protective radiosensitive intraepithelial l ymphocytes, and radiation-induced priming of intradermal macrophages.