BRAIN AGING AND NEUROTRANSPLANTATION .1. NIGRAL CELL-SUSPENSION CRAFTTO AGED RODENT STRIATUM AND MOTOR DISABILITIES

Authors
FERNANDEZ C DELACUETARA K CASTELLANOS O GONZALEZ O NUNEZ N ALVAREZ L MACIAS R TORRES A PERNAS R SOTO J MOLINA H SOLER W
Citation
C. Fernandez et al., BRAIN AGING AND NEUROTRANSPLANTATION .1. NIGRAL CELL-SUSPENSION CRAFTTO AGED RODENT STRIATUM AND MOTOR DISABILITIES, Archives of gerontology and geriatrics, 1994, pp. 51-58
Citations number
19
Categorie Soggetti
Geiatric & Gerontology
Journal title
Archives of gerontology and geriatrics → ACNP
ISSN journal
01674943
Year of publication
1994
Supplement
4
Pages
51 - 58
Database
ISI
SICI code
0167-4943(1994):<51:BAAN.N>2.0.ZU;2-3
Abstract
The possibilities of neural transplantation were studied in functional motor recovery of 21-23-month-old Sprague-Dawley male rats. Age-depen dent functional losses of rats were evaluated using the Marshall scale for swimming abilities, narrow bridge task and suspension on horizont al wire. Fifteen rats exhibited motor disabilities when were compared with young control rats. Deficient rats were divided in two groups: on e group received dissociated fetal dopaminergic cells from ventral mes encephalon (E12-E14) to striatum, whereas the other group having the s ame level of impairment, was followed without any graft and served as age-matched controls. Cell survival and behavior were evaluated twelve weeks after grafting by immunocytochemistry (tyrosine hydroxylase = T H) and the same behavioral test battery.