Our understanding of viral hepatitis becomes greater with time. The ub
iquitous hepatitis A virus could soon become obsolete with advances in
the development of new vaccines. Hepatitis B is well characterized by
its serologic markers and the potential role of the polymerase chain
reaction. Its presentation and prognosis can be influenced by the deve
lopment of cirrhosis, concurrent immunocompromised states, and age. Th
e transmission, diagnosis, and long-term prognosis of chronic hepatiti
s C is becoming less cryptic and more defined with the help of more se
nsitive and specific testing methods and continued patient follow-up.
Close associations to hepatitis C are being established with many othe
r disease states. Hepatitis D and its relationship to hepatitis B are
defined. Finally, an overview of the developing characterization of he
patitis E is also presented.