CHARACTERIZATION, EXPRESSION AND EVOLUTION OF MOUSE BETA(2)-GLYCOPROTEIN-1 (APOLIPOPROTEIN-H)

Authors
SELLAR GC STEEL DM ZAFIROPOULOS A SEERY LT WHITEHEAD AS
Citation
Gc. Sellar et al., CHARACTERIZATION, EXPRESSION AND EVOLUTION OF MOUSE BETA(2)-GLYCOPROTEIN-1 (APOLIPOPROTEIN-H), Biochemical and biophysical research communications, 200(3), 1994, pp. 1521-1528
Citations number
35
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
200
Issue
3
Year of publication
1994
Pages
1521 - 1528
Database
ISI
SICI code
0006-291X(1994)200:3<1521:CEAEOM>2.0.ZU;2-D
Abstract
beta(2)-glycoprotein I (beta(2)I) is a 50kDa serum glycoprotein of ill defined function. Based upon its capacity to bind negatively charged phospholipids a number of possible inhibitory roles for beta(2)I have been proposed. We have cloned and sequenced a full length mouse beta(2 )I cDNA clone and demonstrated that mouse beta(2)I does not behave as an acute phase reactant following an experimentally induced inflammati on. Phylogenetic analysis of the known mammalian beta(2)I homologues h as provided evidence that mouse beta(2)I is the most divergent and is evolving at a faster rate than beta(2)I in other species. (C) 1994 Aca demic Press, Inc.