IDENTIFICATION OF THE MOUSE HELPER T-LYMPHOCYTE DIFFERENTIATION ANTIGEN 3G11 AS TBE GANGLIOSIDE IV3(NEUAC)(2)-GGOSE(4)CER

Authors
DITTRICH F HAYAKAWA K NIMTZ M EBEL F MUHLRADT PF
Citation
F. Dittrich et al., IDENTIFICATION OF THE MOUSE HELPER T-LYMPHOCYTE DIFFERENTIATION ANTIGEN 3G11 AS TBE GANGLIOSIDE IV3(NEUAC)(2)-GGOSE(4)CER, Biochemical and biophysical research communications, 200(3), 1994, pp. 1557-1563
Citations number
23
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
200
Issue
3
Year of publication
1994
Pages
1557 - 1563
Database
ISI
SICI code
0006-291X(1994)200:3<1557:IOTMHT>2.0.ZU;2-G
Abstract
The 3G11 antigen, originally defined by the monoclonal antibody SM3G11 , is expressed to different extents by distinct murine CD4(+) T helper cell subsets. This antigen was isolated from a 3G11(+) murine thymoma by lipid extraction. Upon further purification 3G11 antigen was enric hed in the disialoganglioside fraction and was finally purified by HPL C. Compositional and methylation analysis, liquid secondary ion mass s pectroscopy (LSI-MS) and comparison with an authentic sample resulted in identification of the 3G11 antigen as the disialoganglioside IV3(Ne uAc)(2)-GgOse(4)Cer. (C) 1994 Academic Press, Inc.