COGNITIVE IMPAIRMENTS INDUCED BY TRIAZOLAM IN HEALTHY-VOLUNTEERS - ANTAGONISM BY A PARTIAL INVERSE AGONIST OF BENZODIAZEPINE RECEPTOR

Pharmacological studies revealed that SR 25776 possesses marked stimul ant activity characteristic of a partial inverse agonist of benzodiaze pine receptor The effects of SR 25776 500 mg alone and in combination with triazolam 0.25 mg on psychomotor performance and memory were asse ssed in 8 healthy consenting male volunteers in a double-blind placebo controlled trial. Treatment effects were monitored before and two and half hours following oral medication. The present study suggest that at the studied dose SR 25776 may incompletely antagonize the sedative and amnesic effects of a benzodiazepine agonist without producing mark ed effects of its own.