LINKAGE ANALYSIS OF IL4 AND OTHER CHROMOSOME 5Q31.1 MARKERS AND TOTALSERUM IMMUNOGLOBULIN-E CONCENTRATIONS

Authors
MARSH DG NEELY JD BREAZEALE DR GHOSH B FREIDHOFF LR EHRLICHKAUTZKY E SCHOU C KRISHNASWAMY G BEATY TH
Citation
Dg. Marsh et al., LINKAGE ANALYSIS OF IL4 AND OTHER CHROMOSOME 5Q31.1 MARKERS AND TOTALSERUM IMMUNOGLOBULIN-E CONCENTRATIONS, Science, 264(5162), 1994, pp. 1152-1156
Citations number
63
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
264
Issue
5162
Year of publication
1994
Pages
1152 - 1156
Database
ISI
SICI code
0036-8075(1994)264:5162<1152:LAOIAO>2.0.ZU;2-Y
Abstract
Sib-pair analysis of 170 individuals from 11 Amish families revealed e vidence for linkage of five markers in chromosome 5q31.1 with a gene c ontrolling total serum immunoglobulin E (IgE) concentration. No linkag e was found between these markers and specific IgE antibody concentrat ions. Analysis of total IgE within a subset of 128 IgE antibody-negati ve sib pairs confirmed evidence for linkage to 5q31.1, especially to t he interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE pro duction in a nonantigen-specific (noncognate) fashion.