ADSORPTION AND ASSOCIATION OF 6-THIOPURINE AND 6-THIOPURINE RIBOSIDE AT CHARGED INTERFACES

A systematic study on the adsorption and association of 6-thiopurine ( 6-TP) and 6-thiopurine riboside (6-TPR) has been carried out at variou s pH values and the adsorption parameters were determined quantitative ly. The adsorption was followed by out-of-phase alternating current vo ltammetry and cyclic voltammetry at a hanging mercury drop electrode. A comparative study was undertaken on the adsorption and association o f the investigated thiopurines and the similar type of nucleic acid co mponents containing purine bases. The base-containing thio group enhan ces stacking interaction and facilitates formation of the perpendicula rly stacked layer on the electrode surface.