STERIC EFFECT OP A BULKY SUBSTITUENT AT 5'-POSITION ON THE REGIOSELECTIVITY OF 2' VS 3'-O-METHYLATION OF N-6-CYCLOHEXYLADENOSINE

Authors
PRASHAD M PRASAD K REPIC O
Citation
M. Prashad et al., STERIC EFFECT OP A BULKY SUBSTITUENT AT 5'-POSITION ON THE REGIOSELECTIVITY OF 2' VS 3'-O-METHYLATION OF N-6-CYCLOHEXYLADENOSINE, Nucleosides & nucleotides, 13(4), 1994, pp. 945-952
Citations number
8
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
4
Year of publication
1994
Pages
945 - 952
Database
ISI
SICI code
0732-8311(1994)13:4<945:SEOABS>2.0.ZU;2-X
Abstract
Steric effect of a trityl or substituted trityl group at 5'-OH of N-6- cyclohexyladenosine on the regioselective 2' vs. 3'-O-methylation unde r phase transfer catalysis conditions was investigated. Compound 4 sho wed only a modest increase in the selectivity of 2' over 3'-O-methylat ion compared to compound 1.