INFLUENCE OP REMOTE STRUCTURE UPON REGIOSELECTIVITY IN THE N-ALKYLATION OF 2-AMINO-6-CHLOROPURINE - APPLICATION TO THE SYNTHESIS OF PENCICLOVIR

Authors
CHOUDARY BM GEEN GR GRINTER TJ MACBEATH FS PARRATT MJ
Citation
Bm. Choudary et al., INFLUENCE OP REMOTE STRUCTURE UPON REGIOSELECTIVITY IN THE N-ALKYLATION OF 2-AMINO-6-CHLOROPURINE - APPLICATION TO THE SYNTHESIS OF PENCICLOVIR, Nucleosides & nucleotides, 13(4), 1994, pp. 979-996
Citations number
20
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
4
Year of publication
1994
Pages
979 - 996
Database
ISI
SICI code
0732-8311(1994)13:4<979:IORSUR>2.0.ZU;2-1
Abstract
Reaction of 2-amino-6-chloropurine with trans-2-alkyl-5-iodoethyl-1,3- dioxanes under basic conditions afforded N-9 and N-7 alkylated product s, the product ratio obtained being dependent on the size of the 2-alk yl group. This allowed a highly regioselective key step in the synthes is of the anti-herpes agent penciclovir.