PENTOXIFYLLINE-ASSOCIATED REDUCTION OF INDOMETHACIN-INDUCED RAT GASTRIC-MUCOSAL INJURY IS SUPPORTED BY DECREASED LIPID-PEROXIDATION

Authors
SALLINGOVA Z KOHUT A
Citation
Z. Sallingova et A. Kohut, PENTOXIFYLLINE-ASSOCIATED REDUCTION OF INDOMETHACIN-INDUCED RAT GASTRIC-MUCOSAL INJURY IS SUPPORTED BY DECREASED LIPID-PEROXIDATION, Physiological Research, 43(2), 1994, pp. 95-99
Citations number
31
Categorie Soggetti
Physiology
Journal title
Physiological Research → ACNP
ISSN journal
08628408
Volume
43
Issue
2
Year of publication
1994
Pages
95 - 99
Database
ISI
SICI code
0862-8408(1994)43:2<95:PROIRG>2.0.ZU;2-8
Abstract
Pentoxifylline pretreatment protects rat gastric mucosa against indome thacin-induced damage. Lipid peroxidation after indomethacin treatment (determined as thiobarbituric acid reactants) was significantly reduc ed by a single dose of pentoxifylline. The same was true for pentoxify lline administration for 6 days. There is a relationship between reduc ed lipid peroxidation, decreased number of circulating activated neutr ophils and diminished disposition for acute gastric mucosal lesions in duced by indomethacin in pentoxifylline-pretreated rats.