ANTI-MALARIA ACTIVE 10H-INDOL[3,2-B]QUINO LINE-11-YLAMINES .1. PHENOL-MANNICH-BASES OF THE AMODIAQUINE AND CYCLOQUINE TYPE

Authors
GORLITZER K STOCKMANN R WALTER RD
Citation
K. Gorlitzer et al., ANTI-MALARIA ACTIVE 10H-INDOL[3,2-B]QUINO LINE-11-YLAMINES .1. PHENOL-MANNICH-BASES OF THE AMODIAQUINE AND CYCLOQUINE TYPE, Die Pharmazie, 49(4), 1994, pp. 231-235
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
4
Year of publication
1994
Pages
231 - 235
Database
ISI
SICI code
0031-7144(1994)49:4<231:AA1L.P>2.0.ZU;2-G
Abstract
The 11-chloro-quindoline derivatives 3 react with 4-aminophenol and th e mono- and bis-phenol-Mannich-bases 6 to yield the 10 H-indolo[3,2-b] quinoline-11-yl-amines 4 and 7. The amodiaquine analogue 7a as the bes t of all compounds shows a comparable activity with choroquine and inh ibits a multiresistant Plasmodium falciparum strain at the same concen tration. Compound 7e from the cycloquine-type was selected for an in v ivo antitumor screening programme.