TERNARY MIXTURES OF COLLAGEN DERIVED TENS IDE KLH-3000, LIPIDS AND WATER

We tested a new, collagen derived tenside (KLH-Tensid 3000) for its su itability as an emulsifying agent in pharmaceutical formulations, e.g. creams. KLH-Tensid 3000 as a water soluble but lipid insoluble agent was investigated in ternary systems composed of emulsifier, water and lipid. The results demonstrate, that the solubilizing capacity of KLH- Tensid 3000 for paraffin, isopropylmyristate, middlechain triglyceride s and octyldodecanol is below 1% in micellar solutions. By analyzing t he coalescence of dispersed lipid droplets it is concluded that a good stabilization of the interface is achieved by insertion of the emulsi fier. Ternary mixtures consisted of KLH-Tensid 3000 lipids and water f rom o/w-emulsions over a broad concentration range or preparations wit h an exceeding lipophilic phase. We detected distinct gel preparations with transparent appearance and lipid particles smaller than 100 nm d etermined by transmission electron microscopy. However, no microemulsi on gels with swinging effects or other liquid-crystalline structures w ere found.