MAOI ACTIVITY OF THIOSEMICARBAZIDES AND RELATED 2-THIAZOLYLHYDRAZINES

The preparation is described of hydrazides I, thiosemicarbazides II, I II, IV and hydrazinothiazoles VIII, which can be considered as ''precu rsors'' or ''open models'' for the synthesized benzoyl-, benzilidene- and benzyl-hydrazinothiazoles V, VI and VII, analogous to 4-methyl and 4-phenyl substituted derivatives A, B and C, described and tested for their MAOI activity in a previous paper. Biochemical assay on the new prepared compounds allowed us to better clarify the structure-activit y relationship also of compounds A, B and C of the precedent note. Mor eover, on a group of derivatives, which showed a higher activity, a fu rther test was performed to observe the possible correlation between M AOI activity and both their lipophilicity and ability in interacting w ith liposome bilayers, taken as a model of cell membrane.