CLASS-I AND CLASS-II MAJOR HISTOCOMPATIBILITY MOLECULES PLAY A ROLE IN BONE-MARROW-DERIVED MACROPHAGE DEVELOPMENT

Authors
ARMSTRONG JW SIMSKE SJ BEHARKA AA BALCH S LUTTGES MW CHAPES SK
Citation
Jw. Armstrong et al., CLASS-I AND CLASS-II MAJOR HISTOCOMPATIBILITY MOLECULES PLAY A ROLE IN BONE-MARROW-DERIVED MACROPHAGE DEVELOPMENT, Journal of leukocyte biology, 55(5), 1994, pp. 658-661
Citations number
27
Categorie Soggetti
Immunology,Hematology
Journal title
Journal of leukocyte biology → ACNP
ISSN journal
07415400
Volume
55
Issue
5
Year of publication
1994
Pages
658 - 661
Database
ISI
SICI code
0741-5400(1994)55:5<658:CACMHM>2.0.ZU;2-8
Abstract
Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We s how that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in m acrophage development.