SYNTHESIS OF A PYRIMIDINE ISOSTERE OF THE N-METHYL-D-ASPARTATE ANTAGONIST SDZ-EAB-515

Authors
CAI CZ BUECHLER D LOWE D URWYLER S SHAPIRO G
Citation
Cz. Cai et al., SYNTHESIS OF A PYRIMIDINE ISOSTERE OF THE N-METHYL-D-ASPARTATE ANTAGONIST SDZ-EAB-515, Tetrahedron, 50(19), 1994, pp. 5735-5740
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
19
Year of publication
1994
Pages
5735 - 5740
Database
ISI
SICI code
0040-4020(1994)50:19<5735:SOAPIO>2.0.ZU;2-8
Abstract
The synthesis of a pyrimidine isostere 2 of the potent N-methyl-D-aspa rtate (NMDA) receptor antagonist SDZ EAB 515, 1, has been achieved. Su rprisingly, isostere 2 is more than two orders of magnitude less activ e than 1.