BIOCOMPATIBILITY OF SMALL-INTESTINAL SUBMUCOSA IN URINARY-TRACT AS AUGMENTATION CYSTOPLASTY GRAFT AND INJECTABLE SUSPENSION

We explored the biocompatibility of fluidized canine small-intestinal submucosa (SIS) for periureteral injection and as a patch graft for bl adder augmentation in pigs. Gross evaluation 8 weeks after submucosal injection showed persistence of the nodule. Histologic examination sho wed thickened submucosa with spindle cells embedded in poorly organize d fibrous material. There was no evidence of inflammatory reaction or granuloma formation. Subserosal nodules likewise persisted and demonst rated capillary ingrowth. Grafts of SIS became epithelialized within 3 weeks with maintenance of bladder capacity. Ingrowth of capillaries a nd smooth muscle could be seen in later specimens. Although further st udies with longer follow-up are needed, SIS appears to be a promising graft material in the urinary tract.