Dd. Kitts et An. Wijewickreme, EFFECT OF DIETARY CAFFEIC AND CHLOROGENIC ACIDS ON IN-VIVO XENOBIOTICENZYME-SYSTEMS, Plant foods for human nutrition, 45(3), 1994, pp. 287-298
The plant phenols chlorogenic and caffeic acids were tested for their
affinity to alter hepatic and intestinal xenobiotic Phase I and Phase
II enzyme activities in mice. Mice were fed isocaloric and isonitrogen
ous powdered diets containing 0 and 0.2% caffeic and chlorogenic acids
, respectively. Animals pre-treated with benzo(a)pyrene (B(a)P) were s
acrificed 18 h after an oral dose (50 mg/kg Bwt). B(a)P induced animal
s exhibited higher (p < 0.05) microsomal AHH, UDPGT, P-450 and cytosol
ic GST liver enzyme activities. The presence of these phenolics in the
diet was shown to have little effect in modulating hepatic xenobiotic
activating-detoxification enzymes. The dietary intake of caffeic and
chlorogenic acids was particularly evident with intestinal xenobiotic
AHH and GST enzyme activity. These data indicate that the presence of
caffeic and chlorogenic acids in the diet may have an integral role in
modulating the carcinogenic potential of reactive xenobiotics such as
B(a)P.