S. Arshinoff et al., USE OF TOPICAL NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN EXCIMER-LASER PHOTOREFRACTIVE KERATECTOMY, Journal of cataract and refractive surgery, 20, 1994, pp. 216-222
Nonsteroidal anti-inflammatory drugs (NSAIDs) produce potent analgesic
, antipyretic, and anti-inflammatory effects. We studied postoperative
pain in 97 consecutive patients having photorefractive keratectomy (P
RK) by an excimer laser with different topical NSAID protocols. Treatm
ent with topical homatropine hydrobromide, either diclofenac sodium (V
oltaren Ophthalmic(R)) or ketorolac tromethamine (Acular(R)), and a so
ft contact lens was most effective in achieving post-PRK analgesia. We
also studied post-PRK myopic regression in 68 consecutive patients an
d found that flurbiprofen sodium (Ocufen(R)), when added to topical st
eroid protocols, significantly reduced myopic regression for one year
postoperatively more than steroids alone or steroids and diclofenac so
dium. Diclofenac, used with topical steroids, had less of an additive
effect on myopic regression than did flurbiprofen. Topical NSAIDs are
useful adjuncts to PRK therapy, both to eliminate postoperative pain a
nd to control post-PRK myopic regression.