Endothelial cell counts, morphology, and 24-hour postoperative intraoc
ular pressure (IOP) changes were measured in 55 consecutive patients (
60 eyes) who had uncomplicated phacoemulsification and posterior chamb
er lens implantation with either aspirated (30 eyes) or retained (30 e
yes) Viscoat(R) (sodium chondroitin sulfate-sodium hyaluronate). The s
urgical technique was standardized in all cases. Endothelial cell loss
was almost identical in the aspirated and in the retained groups (8.8
% and 8.7%). Postoperative pleomorphism was significantly less in the
retained Viscoat group than in the aspirated group, suggesting a possi
ble protective effect of the retained viscoelastic. Corneal thickness
increased significantly in the retained Viscoat group, but this was no
t significant clinically. The retained Viscoat group had more patients
with a postoperative IOP greater than 30 mm Hg and a greater mean inc
rease in postoperative IOP, although the difference between the groups
was not significant. The IOP changes may have been caused by blockage
of the trabecular meshwork by the retained Viscoat. The results sugge
st that Viscoat can be retained after cataract surgery if the surgeon
is prepared for a greater 24-hour postoperative increase in IOP.