SYNTHESIS OF NOVEL FLUORINATED BISPHOSPHONATES AND BISPHOSPHONIC ACIDS

Authors
NAIR HK GUNERATNE RD MODAK AS BURTON DJ
Citation
Hk. Nair et al., SYNTHESIS OF NOVEL FLUORINATED BISPHOSPHONATES AND BISPHOSPHONIC ACIDS, Journal of organic chemistry, 59(9), 1994, pp. 2393-2398
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
9
Year of publication
1994
Pages
2393 - 2398
Database
ISI
SICI code
0022-3263(1994)59:9<2393:SONFBA>2.0.ZU;2-E
Abstract
The synthesis of novel fluorinated bisphosphonates with two, three, fo ur, and six difluoromethylene groups (1a, 1b, 8, 12, and 15) (44-78%) by different approaches is described. The bisphosphonates were convert ed to the corresponding trimethylsilyl esters which on treatment with deionized water afforded the respective bisphosphonic acids (6, 10, an d 14) in good yields.