CLONING OF 2 NOVEL ABC TRANSPORTERS MAPPING ON HUMAN-CHROMOSOME-9

The family of ATP binding cassette (ABC) transporters or traffic ATPas es is composed of several membrane-associated proteins that transport a great variety of solutes across cellular membranes. Two novel mammal ian members of the family, ABC1 and ABC2, have been identified by a PC R-based approach. They belong to a group of traffic ATPases encoded as a single multifunctional protein, such as CFTR, STE 6, and P-glycopro teins. Their peculiar structural features and close relationship to AB C transporters involved in nodulation suggest that ABC1 and ABC2 defin e a novel subgroup of mammalian traffic ATPases. (C) 1994 Academic Pre ss, Inc.