LOCALIZATION OF THE OTF3 GENE WITHIN THE HUMAN MHC CLASS-I REGION BY PHYSICAL AND MEIOTIC MAPPING

Authors
CROUAUROY B AMADOU C BOUISSOU C CLAYTON J VERNET C RIBOUCHON MT PONTAROTTI P
Citation
B. Crouauroy et al., LOCALIZATION OF THE OTF3 GENE WITHIN THE HUMAN MHC CLASS-I REGION BY PHYSICAL AND MEIOTIC MAPPING, Genomics, 21(1), 1994, pp. 241-243
Citations number
15
Categorie Soggetti
Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
21
Issue
1
Year of publication
1994
Pages
241 - 243
Database
ISI
SICI code
0888-7543(1994)21:1<241:LOTOGW>2.0.ZU;2-Y
Abstract
OTF3 (octamer transcription factor 3) is a transcription factor contai ning a POU-specific domain and a homeodomain that could play-a role in early development. In situ hybridization and pairwise linkage analysi s showed that OTF3 gene maps close to the human MHC (major histocompat ibility complex). In this paper, we define its localization within the MHC, around 100 kb telomeric to HLA-C, using a combination of physica l and genetic analyses. (C) 1994 Academic Press, Inc.