HUMAN G-PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL (GIRK1)GENE (KCNJ3) - LOCALIZATION TO CHROMOSOME-2 AND IDENTIFICATION OF A SIMPLE TANDEM REPEAT POLYMORPHISM

The gene encoding the human G-protein-coupled inwardly rectifying pota ssium channel designated GIRK1 (gene symbol, KCNJ3) was mapped to chro mosome 2 by analyzing its segregation in a panel of human-hamster soma tic cell hybrids. This assignment was confirmed by fluorescence in sit u hybridization to metaphase chromosomes, and the gene was further loc alized to band 2q24.1. A highly informative simple tandem repeat DNA p olymorphism of the form (CA), was identified and used to localize KCNJ 3 within the genetic map of the long arm of chromosome 2. (C) 1994 Aca demic Press, Inc.