ASSOCIATION OF KM(3) ALLOTYPE WITH INCREASED SERUM LEVELS OF AUTOANTIBODIES AGAINST MUSCLE ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS

Authors
DONDI E GAJDOS P BACH JF GARCHON HJ
Citation
E. Dondi et al., ASSOCIATION OF KM(3) ALLOTYPE WITH INCREASED SERUM LEVELS OF AUTOANTIBODIES AGAINST MUSCLE ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS, Journal of neuroimmunology, 51(2), 1994, pp. 221-224
Citations number
31
Categorie Soggetti
Neurosciences,Immunology
Journal title
Journal of neuroimmunology → ACNP
ISSN journal
01655728
Volume
51
Issue
2
Year of publication
1994
Pages
221 - 224
Database
ISI
SICI code
0165-5728(1994)51:2<221:AOKAWI>2.0.ZU;2-7
Abstract
Association of immunoglobulin allotypes with myasthenia gravis was exa mined in a set of 84 patients presenting autoantibodies against muscle acetylcholine receptor (AChR). Km and G1m(f)/G1m(z) allotypes were de termined by PCR-amplification followed by hybridization with allele-sp ecific oligonucleotides. The Km(3) kappa light chain allotype was foun d to be associated with significantly increased serum levels of anti-A ChR autoantibodies in myasthenic patients (P = 0.014). We hypothesize that an allelic polymorphism of a regulatory (enhancer) sequence close ly linked to the CK gene segment could account for our finding.