Mg. Garry et al., CARRAGEENAN-INDUCED INFLAMMATION ALTERS THE CONTENT OF I-CGMP AND I-CAMP IN THE DORSAL HORN OF THE SPINAL-CORD, Brain research, 646(1), 1994, pp. 135-139
Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal lat
encies to radiant heat and increased hindpaw edema. At the peak of hyp
eralgesia, the content of immunoreactive guanosine 3',5'-cyclic monoph
osphate (i-cGMP) was increased, while immunoreactive adenosine 3',5'-c
yclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical
dorsal horn. In general, the content of i-cGMP in the dorsal horn was
correlated with thermal hyperalgesia throughout the course of this mo
del. These results indicate that a peripheral inflammation alters the
content of i-cGMP and i-cAMP in the spinal cord and, further, suggest
that these nucleotides are involved in the modulation of hyperalgesia
in the spinal cord.