EFFECT OF ENDOGENOUS ORGANIC HYPERINSULINEMIA ON BLOOD-PRESSURE AND SERUM TRIGLYCERIDES

Hyperinsulinaemia and insulin resistance have been hypothesized to be the common pathophysiological factor of hypertension, NIDDM and obesit y. To evaluate the possible role of hyperinsulinaemia and insulin resi stance on hypertension, we studied a group of 37 patients with insulin oma who were admitted to our department in the period from 1966 to 199 0. We recorded blood pressure and assayed blood glucose, plasma insuli n, plasma triglycerides and serum uric acid levels, before and after s urgery, in these patients and in a 37-subject control group. No signif icant increase in blood pressure and triglyceride plasma levels was re corded in the chronic hyperinsulinaemic hypoglycaemic patients, sugges ting the lack of a direct role of hyperinsulinaemia on hypertension.