TOPICAL APPLICATION OF A CYCLIC-GMP ANALOG LOWERS IOP IN NORMAL AND OCULAR HYPERTENSIVE RABBITS

Purpose. To determine whether a new cyclic GMP analog, 2'-O-(4-benzoyl )benzoylguanosine 3',5' cyclic monophosphate (BB-cCMP), significantly reduces intraocular pressure in either normotensive or hypertensive ey es of rabbits. Methods. Intraocular pressure of normal adult rabbits a nd/or rabbits with alpha-chymotrypsin-induced ocular hypertension was measured after topical application of BB-cGMP for up to 72 hours after treatment. Results. Data indicate that topical application of solutio ns containing BB-cGMP can significantly reduce intraocular pressure in normotensive eyes and, to a greater extent, hypertensive eyes for per iods up to 12 hours for a single dose. Conclusions. BB-cGMP holds inte rest both as a clinical agent in the management of intraocular pressur e and for in vitro biochemical studies on the regulation of intraocula r pressure.