DIFFERENTIAL MOOD RESPONSE TO NATURAL AND SYNTHETIC CORTICOSTEROIDS AFTER BILATERAL ADRENALECTOMY - A CASE-REPORT

Authors
SEIFRITZ E HEMMETER U POLDINGER W FROESCH ER REUL JMHM HOLSBOERTRACHSLER E
Citation
E. Seifritz et al., DIFFERENTIAL MOOD RESPONSE TO NATURAL AND SYNTHETIC CORTICOSTEROIDS AFTER BILATERAL ADRENALECTOMY - A CASE-REPORT, Journal of Psychiatric Research, 28(1), 1994, pp. 7-11
Citations number
20
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
Journal of Psychiatric Research → ACNP
ISSN journal
00223956
Volume
28
Issue
1
Year of publication
1994
Pages
7 - 11
Database
ISI
SICI code
0022-3956(1994)28:1<7:DMRTNA>2.0.ZU;2-Y
Abstract
A 48-year-old woman who had had a bilateral adrenalectomy for Cushing' s syndrome developed severe psychotic symptoms that were unresponsive to psychotropic drugs as long as she was taking prednisone (PRED) as r eplacement therapy. However, after she was switched to a regimen of co rtisol (CORT) and fludrocortone (FLUD) the psychopathology disappeared . Mechanisms related to the differences in the interaction of natural (e.g. CORT) and synthetic (e.g. PRED) corticosteroids with the central glucocorticoid and mineralocorticoid receptors may explain the differ ent effects upon psychopathology.