ACUTE CARDIOVASCULAR EFFECTS OF COCAETHYLENE AND COCAINE IN RATS

Authors
WANG YL WALKER LA DAVIS WM
Citation
Yl. Wang et al., ACUTE CARDIOVASCULAR EFFECTS OF COCAETHYLENE AND COCAINE IN RATS, Research communications in substance abuse, 14(4), 1993, pp. 217-226
Citations number
15
Categorie Soggetti
Substance Abuse
Journal title
Research communications in substance abuse → ACNP
ISSN journal
01930818
Volume
14
Issue
4
Year of publication
1993
Pages
217 - 226
Database
ISI
SICI code
0193-0818(1993)14:4<217:ACEOCA>2.0.ZU;2-4
Abstract
The acute cardiovascular response of anesthetized rats was recorded af ter i.v. dosing with cocaine (COC) or with its metabolite, in the pres ence of ethanol, cocaethylene (COCET). The two agents had similar pres sor effects in the range 0.061-0.61 mumol/kg, both causing dose-depend ent increase of maximal mean arterial pressure. The slope of the dose- effect curve for COCET was steeper than for COC.