ANTICIPATION IN MYOTONIC-DYSTROPHY - A PARENTAL-SEX-RELATED PHENOMENON

Authors
DEMUNAIN AL BLANCO A EMPARANZA JI MASSO JFM COBO A BASAURI B MARTORELL L BAIGET M LAGE JMM
Citation
Al. Demunain et al., ANTICIPATION IN MYOTONIC-DYSTROPHY - A PARENTAL-SEX-RELATED PHENOMENON, Neuroepidemiology, 13(1-2), 1994, pp. 75-78
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Neuroepidemiology → ACNP
ISSN journal
02515350
Volume
13
Issue
1-2
Year of publication
1994
Pages
75 - 78
Database
ISI
SICI code
0251-5350(1994)13:1-2<75:AIM-AP>2.0.ZU;2-U
Abstract
We report anticipation in an extensive sample of myotonic dystrophy (M yD) kindreds taken from an epidemiological survey recently conducted i n Guipuzcoa, Spain. Analysis of the parent-child pairs ascertained sho wed a mean anticipation of 2.86 decades (range 0-6). Greater anticipat ion occurred when the transmissor parent was the mother. These results suggest a possible sex-related effect in the transmission of the MyD gene, and are in agreement with recent discoveries at the molecular le vel.