REGULATION OF ADHESION-RELATED PROTEIN-TYROSINE KINASES DURING IN-VITRO DIFFERENTIATION OF RETINAL-PIGMENT EPITHELIAL-CELLS - TRANSLOCATIONOF PP60(C-SRC) TO THE NUCLEUS IS ACCOMPANIED BY DOWN-REGULATION OF PP125(FAK)

Authors
MOSZCZYNSKA A OPAS M
Citation
A. Moszczynska et M. Opas, REGULATION OF ADHESION-RELATED PROTEIN-TYROSINE KINASES DURING IN-VITRO DIFFERENTIATION OF RETINAL-PIGMENT EPITHELIAL-CELLS - TRANSLOCATIONOF PP60(C-SRC) TO THE NUCLEUS IS ACCOMPANIED BY DOWN-REGULATION OF PP125(FAK), Biochemistry and cell biology, 72(1-2), 1994, pp. 43-48
Citations number
68
Categorie Soggetti
Biology
Journal title
Biochemistry and cell biology → ACNP
ISSN journal
08298211
Volume
72
Issue
1-2
Year of publication
1994
Pages
43 - 48
Database
ISI
SICI code
0829-8211(1994)72:1-2<43:ROAPKD>2.0.ZU;2-X
Abstract
In the present report we show that induction of expression of a differ entiated phenotype in cultured retinal pigmented epithelium of chick e mbryo is accompanied by coordinate regulation of expression and distri bution of two adhesion-related nonreceptor protein tyrosine kinases, p p60(c-src) and pp125(FAK). pp60(c-src) translocates from the cell surf ace in flat undifferentiated cells to the nucleus in the packed differ entiated cells. In contrast, pp125(FAK), abundant in focal adhesions o f flat undifferentiated cells, is downregulated in cells that have dif ferentiated and packed into an epithelial sheet.