ROLE OF PAPILLOMAVIRUS ONCOGENES IN HUMAN CERVICAL-CANCER - TRANSGENIC ANIMAL STUDIES

Human papillomaviruses are believed to be etiologic agents for the maj ority of human cervical carcinoma, a common cancer that is a leading c ause of death by cancer among women worldwide. In cervical carcinoma, a subset of papillomaviral genes, namely E6 and E7, are expressed. In vitro tissue culture studies indicate that HPV E6 and E7 are oncogenes , and that their oncogenicity is due in part to their capacity to inac tivate cellular tumor suppressor genes. The behavior of E6 and E7 in v itro and the genetic evidence from analysis of human cancers suggest t hat the E6 and E7 genes play a significant role in the development of cervical cancer. This hypothesis is now being tested using animal mode ls. In this review, we summarize our current knowledge of the oncogeni city of papillomavirus genes that has been generated through their stu dy in transgenic mice.