NUCLEAR ONCE-PROTEIN TARGETS OF SIGNAL-TRANSDUCTION PATHWAYS

Citation
Jr. Woodgett et al., NUCLEAR ONCE-PROTEIN TARGETS OF SIGNAL-TRANSDUCTION PATHWAYS, Pigment cell research, 7(2), 1994, pp. 96-100
Citations number
38
Categorie Soggetti
Cytology & Histology
Journal title
ISSN journal
08935785
Volume
7
Issue
2
Year of publication
1994
Pages
96 - 100
Database
ISI
SICI code
0893-5785(1994)7:2<96:NOTOSP>2.0.ZU;2-4
Abstract
Irradiation of mammalian cells with ultraviolet light (200-400 nm) res ults in the activation of a number of genes, the so-called ''UV respon se'' (Herrlich et al., Rev. Physiol. Biochem. Pharmacol., 119:187-223, 1992). Many of the UV responsive genes are also transcriptionally act ivated by growth factors and mitogens. Two transcription factors have been demonstrated to acutely respond to these stimuli, namely AP-1 and NF-kappa B. Whereas NF-kappa B proteins are primarily controlled via proteolysis of regulatory domains which prevent nuclear translocation, the AP-1 proteins are regulated at several levels including transcrip tion and posttranslational modification. Here, we discuss progress in the identification of the components of pathways acutely regulating th ese transcription factors.