HYPOTHESIS - THE INFLUENCE OF SEX IN ARTHRITIS - IS CARTILAGE AN OVERLOOKED FACTOR

Citation
Jap. Dasilva et Da. Willoughby, HYPOTHESIS - THE INFLUENCE OF SEX IN ARTHRITIS - IS CARTILAGE AN OVERLOOKED FACTOR, Journal of rheumatology, 21(5), 1994, pp. 791-796
Citations number
98
Categorie Soggetti
Rheumatology
Journal title
ISSN journal
0315162X
Volume
21
Issue
5
Year of publication
1994
Pages
791 - 796
Database
ISI
SICI code
0315-162X(1994)21:5<791:H-TIOS>2.0.ZU;2-O
Abstract
Sex emerges as a predominant risk and prognostic factor from epidemiol ogical studies in a variety of rheumatic diseases. Investigations into the underlying mechanisms stress sex related differences in immune an d inflammatory responses. Cartilage destruction is an essential featur e of most arthropathies and plays an essential role in the symptomatol ogy and progression of arthritis. Based on published evidence and rece nt experimental observations, we explore the possibility that sex diff erences in articular cartilage may be an important, though unrecognize d, factor in the effects of sex and related hormones in the progressio n of articular disease.