ASSESSING THE SIGNIFICANCE OF CHROMOSOME-LOSS DATA - WHERE ARE SUPPRESSOR GENES FOR BLADDER-CANCER

Authors
NEWTON MA WU SQ REZNIKOFF CA
Citation
Ma. Newton et al., ASSESSING THE SIGNIFICANCE OF CHROMOSOME-LOSS DATA - WHERE ARE SUPPRESSOR GENES FOR BLADDER-CANCER, Statistics in medicine, 13(8), 1994, pp. 839-858
Citations number
22
Categorie Soggetti
Statistic & Probability","Medicine, Research & Experimental","Public, Environmental & Occupation Heath","Statistic & Probability
Journal title
Statistics in medicine → ACNP
ISSN journal
02776715
Volume
13
Issue
8
Year of publication
1994
Pages
839 - 858
Database
ISI
SICI code
0277-6715(1994)13:8<839:ATSOCD>2.0.ZU;2-V
Abstract
Cytogenetic analysis reveals alterations of chromosome structure (loss es, gains, and rearrangements of genetic material) in bladder cancer c ells generated using an in vitro/in vivo transformation system. To pre dict possible locations of bladder cancer suppressor genes, we perform ed a robust Bayesian analysis of the chromosome-loss data. We postulat ed a simple stochastic model to describe chromosome loss during tumour progression. Posterior computations are enabled by a dynamic simulati on algorithm. Ordered by decreasing posterior probability of putativel y harbouring a suppressor gene, we observe significant losses on chrom osomes 3, 18, 13, 10, 11, and y.