SYNTHESIS AND BIOLOGICAL EVALUATION OF (+ --EPIBATIDINE AND THE CONGENERS/

Authors
SENOKUCHI K NAKAI H KAWAMURA M KATSUBE N NONAKA S SAWARAGI H HAMANAKA N
Citation
K. Senokuchi et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF (+ --EPIBATIDINE AND THE CONGENERS/, Synlett, (5), 1994, pp. 343-344
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
5
Year of publication
1994
Pages
343 - 344
Database
ISI
SICI code
0936-5214(1994):5<343:SABEO(>2.0.ZU;2-B
Abstract
A total synthesis of the non-opiate antinociceptive alkaloid (+/-)-epi batidine and its congeners is described, in which the key step is the reductive elimination of hydroxy function in 8a. The hydrogenolysis of 8a proceeded smoothly with retention of the configuration to afford 9 a. Biological evaluation of these compounds is also included.