RAPID-DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND HYDRALAZINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS BY REVERSE-PHASE LIQUID-CHROMATOGRAPHY

Authors
CABANILLAS AG DIAZ TG SALINAS F CABANILLAS CG
Citation
Ag. Cabanillas et al., RAPID-DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND HYDRALAZINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS BY REVERSE-PHASE LIQUID-CHROMATOGRAPHY, Annali di chimica, 83(11-12), 1993, pp. 523-528
Citations number
4
Categorie Soggetti
Chemistry
Journal title
Annali di chimica → ACNP
ISSN journal
00034592
Volume
83
Issue
11-12
Year of publication
1993
Pages
523 - 528
Database
ISI
SICI code
0003-4592(1993)83:11-12<523:ROPHAH>2.0.ZU;2-C
Abstract
A high speed high-performance liquid chromatographic method has been d eveloped for the determination of propranolol and hydralazine in pharm aceutical dosage forms. A reversed-phase system was used, based on an octadecylsilane-bonded stationary phase and a mobile phase of a 40/60% v/v aqueous solution/acetonitrile. The aqueous solution is 7.5x10(-3) M in dodecyl hydrogen sulfate sodium salt and 1% in acetic acid. The detector response at 230 nm was linearly related to the amount injecte d over a wide range and the method is sensitive, simple, rapid and pre cise.